Active Pharmaceutical Ingredients (APIs) amagwira ntchito yofunika kwambiri pamakampani opanga mankhwala ndipo ndiwo maziko opangira mankhwala onse.
Kukula kwa msika wamakampani opanga mankhwala ku Japan kuli pachiwiri ku Asia.Ndi kuwonjezeka kwa ndalama za R & D zamakampani opanga mankhwala ndi zifukwa zina, zikuyembekezeka kuti msika wa Japan APIs udzakula pamlingo wapamwamba kwambiri wa 7% mpaka 8% pofika 2025. Pakati pawo, makampani opanga mankhwala omwe adagwira nawo ntchito yaikulu akuphatikizapo. Sun Pharmaceutical, Teva, Novartis International AG, Piramal Enterprises, ndi Aurobindo.
Kukula kwa makampani opanga mankhwala osokoneza bongo ku Japan kukukumananso ndi vuto la kusakwanira kokwanira kwa zinthu zopangira.Pafupifupi 50% ya ma API omwe amatumizidwa kunja kwa dziko lapansi amagwiritsidwa ntchito popanga mankhwala amtundu uliwonse, ndipo ogulitsa akuluakulu ochokera kumayiko ena amachokera kumayiko aku Asia ndi Europe monga India, China, South Korea, Italy, Spain, Hungary ndi Germany.Pofuna kuchepetsa kudalira ma API ochokera kunja, Japan ikuyang'ana kwambiri za kumasulira kwa ma API.
Sumitomo Pharmaceuticals, kampani yoyamba ku Japan kupanga mankhwala osokoneza bongo pogwiritsa ntchito luso lapamwamba la organic synthesis, ikukonzekera kumanga API yatsopano ya mankhwala a molekyulu ndi fakitale yapakati ku Oita City, Oita Prefecture.Cholinga chachikulu cha polojekitiyi ndikuwonjezera mphamvu zopanga API za kampani kuti zikwaniritse kufunikira kwa ma API apamwamba komanso apakatikati.
Chomera chatsopanochi chikuyenera kukhazikitsidwa mu September 2024. Dipatimenti yake yokonza mgwirizano ndi kupanga (CDMO) imagwiritsa ntchito teknoloji yapadera kupanga ndi kupereka ma API ang'onoang'ono a molekyulu ndi apakatikati kwa makampani opanga mapangidwe, ndikuzindikira malonda akunja amalonda.Chifukwa cha kufunikira kwakukulu kwa ntchito zatsopano zopangira mankhwala, msika wapadziko lonse wa CDMO wapadziko lonse lapansi ukukula mosalekeza.Akuti mtengo wamalonda wapadziko lonse wamankhwala a CDMO ndi pafupifupi madola 81 biliyoni aku US, ofanana ndi yen 10 thililiyoni.
Podalira njira yake yabwino kwambiri yotsimikizira zaubwino komanso maubwino owongolera zinthu padziko lonse lapansi, Sumitomo Pharmaceuticals yakulitsa bizinesi yake ya CDMO pazaka zambiri ndipo yakhazikitsa malo otsogola ku Japan.Zomera zake ku Gifu ndi Okayama zili ndi mphamvu zochepa zopanga.Mphamvu zopanga zamphamvu za ma API ndi zapakati zomwe zimafunikira pamankhwala ochizira maselo.Opanga mapangano azamankhwala ku Japan a Bushu Corporation adachita mgwirizano ndi Suzuken Pharmaceutical Company mu Epulo 2021 kuti apereke chithandizo chatsopano chamakampani opanga mankhwala omwe akufuna kulowa msika waku Japan.Bushu akuyembekeza kuchita pangano lothandizira kupanga ma API mwachindunji, kudzera mu mgwirizano wamakampani awiri opanga mankhwala, kuti apereke chithandizo chanthawi imodzi pakufunika kwamankhwala apadera, kuphatikiza kukwezedwa kwa omwe ali ndi chilolezo / omwe ali ndi mankhwala osokoneza bongo, kuitanitsa, kuwunika kwa msika, Kupanga ndi kupereka, kusungitsa ndi mayendedwe, kuwunikira kukwezedwa ndi chithandizo cha odwala ndi ntchito zina.
Nthawi yomweyo, Bushu Pharmaceuticals imatha kupereka mankhwala kwa odwala munthawi yonseyi pogwiritsa ntchito njira yapadera yowunikira mankhwala oziziritsa kukhosi (Cubixx) yopangidwa ndi Suzuken Co., Ltd. Kuphatikiza apo, kampani yaku Japan ya Astellas Pharmaceutical Company idawulula kuti malinga ndi dongosolo lachitatu lakukulitsa kupanga, maziko a API opangira mankhwala osakhazikika omwe adakhazikitsidwa ku Toyama, Japan mu Januware 2020 adzagwiritsidwa ntchito kupanga choyambirira cha Astellas Prograf's tacrolimus hydrate API.
Tacrolimus ndi mankhwala omwe amalepheretsa komanso kuchiza kukana kwa chiwalo mwa odwala akulu ndi ana omwe adalandira chiwindi, impso, mtima (ndi mapapo kuvomerezedwa kwatsopano kwa FDA mu 2021).
Nthawi yotumiza: Jun-03-2019
